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Ted Turner recently announced that he has Lewy body dementia, a diagnosis that the late comic and actor Robin Williams was given after his death. The disease is frequently unrecognized even by doctors, despite the fact that Lewy body dementia is the second most common dementia. In one study, almost 70 percent of people diagnosed […]
September is World Alzheimer’s Month, and subjective cognitive decline, or SCD, can be a warning sign for the disease. Symptoms can include losing one’s train of thought, forgetting the content of a movie soon after the credits roll and feeling overwhelmed when making plans or coordinating events. Kim Innes, an epidemiology professor from the West Virginia University School of […]
A University of Adelaide-led team of scientists has suggested a potential link between iron in our cells and the rare gene mutations that cause Alzheimer’s disease, which could provide new avenues for future research. In a paper published in the journal Frontiers in Neuroscience, the team proposes a new theory for how rare gene mutations cause Alzheimer’s […]
(Reuters) – Eisai Co Ltd and Biogen Inc will move forward with late-stage clinical trials of their Alzheimer’s disease drug, BAN2401, and are working with regulators to design the next studies and gain expedited review as a breakthrough therapy. The companies announced this month that despite failing at an earlier stage, the drug slowed Alzheimer’s […]
Deep brain stimulation (DBS) may slow the progression of tremor for early-stage Parkinson’s disease patients, according to a Vanderbilt University Medical Center study released in the June 29 online issue of Neurology®, the medical journal of the American Academy of Neurology. The study is the first evidence of a treatment that slows the progression of one […]
During the past decade, researchers have identified new ways to detect the earliest biological signs of Alzheimer’s disease. These early signs, which are detected by biomarkers, may be present before a person starts to exhibit physical symptoms. What biomarker screening doesn’t reveal, however, is how likely it is that a person who tests positive will […]
Scientists know that faulty proteins can cause harmful deposits or “aggregates” in neurological disorders such as Alzheimer’s and Parkinson’s disease. Although the causes of these protein deposits remain a mystery, it is known that abnormal aggregates can result when cells fail to transmit proper genetic information to proteins. University of California San Diego Professor Susan […]
A recent study from researchers at the Icahn School of Medicine at Mount Sinai provides new insights into a link between inflammatory bowel disease (IBD) and Parkinson’s disease, and may have significant implications for the treatment and prevention of Parkinson’s disease. The recent study, published in JAMA Neurology, shows that individuals with IBD are at […]
Years before people start showing characteristic symptoms of Alzheimer’s disease, sticky plaques begin forming in their brains, damaging nearby cells. For decades, doctors have sought ways to clear out these plaques as a way to prevent or treat the disease. The sticky clumps, known as amyloid plaques, are composed primarily of a brain protein called […]
Concussions and other traumatic brain injuries may increase the risk of developing Alzheimer’s disease earlier in life, according to a study from UT Southwestern’s Peter O’Donnell Jr. Brain Institute. The research – the first to use autopsy-confirmed cases of Alzheimer’s disease to examine the long-term effects of head injuries – supports a correlation that could only be […]
A team of researchers from the Cleveland Clinic Lerner Research Institute have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer’s disease, thereby improving the animals’ cognitive function. The study, which will be published February 14 in the Journal of Experimental Medicine, raises […]
Systemic clearing of senescent astrocytes prevents Parkinson’s neuropathology and associated symptoms in a mouse model of sporadic disease, the type implicated in 95% of human cases. Publishing in Cell Reports, researchers in the Andersen lab at the Buck Institute provide a new potential therapeutic avenue for the incurable, progressive neurological disorder that affects up to one […]
Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells’ chromatin. The study, which will be published December 11 in the Journal of Cell Biology, suggests that targeting this enzyme could make pancreatic cancer cells more vulnerable to existing therapies that currently have only […]
An international team of researchers has shown that a new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer’s disease. The drug works by stopping toxic ion flow in the brain that is known to trigger nerve cell death. Scientists envision that this drug could be used to treat Alzheimer’s […]
Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a peptide that could lead to the early detection of Alzheimer’s disease (AD). The discovery, published in Nature Communications, may also provide a means of homing drugs to diseased areas of the brain to treat AD, Parkinson’s disease, as well as glioblastoma, brain injuries […]
Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have shown that a protein called membralin is critical for keeping Alzheimer’s disease pathology in check. The study, published in Nature Communications, shows that membralin regulates the cell’s machinery for producing beta-amyloid (or amyloid beta, Aβ), the protein that causes neurons to die in Alzheimer’s disease. “Our […]
The challenge with diagnosing chronic traumatic encephalopathy (CTE), a condition that shows up in the overwhelming majority of American football players and other athletes who frequently sustain injuries to the head, is that it can only be diagnosed through an autopsy. Researchers at Medicortex Finland Oy, are working on a diagnostic kit that could detect […]
A gene called triggering receptor expressed on myeloid cells 2, or TREM2, has been associated with numerous neurodegenerative diseases, such as Alzheimer’s disease, Frontotemporal lobar degeneration, Parkinson’s disease, and Nasu-Hakola disease. Recently, a rare mutation in the gene has been shown to increase the risk for developing Alzheimer’s disease. Independently from each other, two research […]
Chronic Traumatic Encephalopathy (CTE) is a slowly developing neurodegenerative condition typical of athletes involved in contact sports. This was evidenced in a recent study in which nearly every former NFL player whose brain was investigated had suffered from CTE. The findings released this week were part of a study conducted by two leading medical institutions devoted […]
People at risk for Alzheimer’s disease who do more moderate-intensity physical activity, but not light-intensity physical activity, are more likely to have healthy patterns of glucose metabolism in their brain, according to a new UW-Madison study. Results of the research were published today online in Journal of Alzheimer’s Disease. Senior author Dr. Ozioma Okonkwo, assistant […]