Alzheimers and Dementia

Study: Brain Injury May Boost Risk of Alzheimer’s Earlier in Life

Concussions and other traumatic brain injuries may increase the risk of developing Alzheimer’s disease earlier in life, according to a study from UT Southwestern’s Peter O’Donnell Jr. Brain Institute. The research – the first to use autopsy-confirmed cases of Alzheimer’s disease to examine the long-term effects of head injuries – supports a correlation that could only be […]

Alzheimers and Dementia

Researchers Successfully Reverse Alzheimer’s Disease in Mouse Model

A team of researchers from the Cleveland Clinic Lerner Research Institute have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer’s disease, thereby improving the animals’ cognitive function. The study, which will be published February 14 in the Journal of Experimental Medicine, raises […]

age-related decline Alzheimers and Dementia

A New Therapeutic Avenue for Parkinson’s disease

Systemic clearing of senescent astrocytes prevents Parkinson’s neuropathology and associated symptoms in a mouse model of sporadic disease, the type implicated in 95% of human cases. Publishing in Cell Reports, researchers in the Andersen lab at the Buck Institute provide a new potential therapeutic avenue for the incurable, progressive neurological disorder that affects up to one […]

Alzheimers and Dementia

Researchers Identify Epigenetic Orchestrator of Pancreatic Cancer Cells

Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells’ chromatin. The study, which will be published December 11 in the Journal of Cell Biology, suggests that targeting this enzyme could make pancreatic cancer cells more vulnerable to existing therapies that currently have only […]

Alzheimers and Dementia

Biomarker May Predict Early Alzheimer’s Disease

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a peptide that could lead to the early detection of Alzheimer’s disease (AD). The discovery, published in Nature Communications, may also provide a means of homing drugs to diseased areas of the brain to treat AD, Parkinson’s disease, as well as glioblastoma, brain injuries […]

Alzheimers and Dementia

New Player in Alzheimer’s Disease Pathogenesis Identified

Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have shown that a protein called membralin is critical for keeping Alzheimer’s disease pathology in check. The study, published in Nature Communications, shows that membralin regulates the cell’s machinery for producing beta-amyloid (or amyloid beta, Aβ), the protein that causes neurons to die in Alzheimer’s disease. “Our […]

Alzheimers and Dementia Biomarkers

A New Clinical Trial for a Novel Brain Injury Biomarker

The challenge with diagnosing chronic traumatic encephalopathy (CTE), a condition that shows up in the overwhelming majority of American football players and other athletes who frequently sustain injuries to the head, is that it can only be diagnosed through an autopsy. Researchers at Medicortex Finland Oy, are working on a diagnostic kit that could detect […]

Alzheimers and Dementia Neurology

Stabilizing TREM2 — a potential strategy to combat Alzheimer’s disease

A gene called triggering receptor expressed on myeloid cells 2, or TREM2, has been associated with numerous neurodegenerative diseases, such as Alzheimer’s disease, Frontotemporal lobar degeneration, Parkinson’s disease, and Nasu-Hakola disease. Recently, a rare mutation in the gene has been shown to increase the risk for developing Alzheimer’s disease. Independently from each other, two research […]

Alzheimers and Dementia Biotechnology

Demand for Diagnostic for Early Detection of Brain Injury After Surprising Study On NFL Players Brains And CTE

Chronic Traumatic Encephalopathy (CTE) is a slowly developing neurodegenerative condition typical of athletes involved in contact sports. This was evidenced in a recent study in which nearly every former NFL player whose brain was investigated had suffered from CTE.  The findings released this week were part of a study conducted by two leading medical institutions devoted […]

Alzheimers and Dementia Biotechnology

Alzheimer’s disease study links brain health and physical activity

People at risk for Alzheimer’s disease who do more moderate-intensity physical activity, but not light-intensity physical activity, are more likely to have healthy patterns of glucose metabolism in their brain, according to a new UW-Madison study. Results of the research were published today online in Journal of Alzheimer’s Disease. Senior author Dr. Ozioma Okonkwo, assistant […]

Alzheimers and Dementia amyotrophic lateral sclerosis Biotechnology

New drug therapy could improve brain function and life expectancy of ALS patients

Ben-Gurion University of the Negev (BGU) researchers are developing a new therapy for Amyotrophic Lateral Sclerosis (ALS) using part of an existing FDA-approved drug that restores the central nervous system’s (CNS) immune defenses and increases life expectancy. ALS, also known as Lou Gehrig’s disease, is a lethal, progressive neurodegenerative disorder that affects the motor nerve […]

Alzheimers and Dementia

Diagnostic biomarkers in saliva show promise in recognizing early Alzheimer’s disease

Your spit may hold a clue to future brain health. Investigators at the Beaumont Research Institute, part of Beaumont Health in Michigan, are hopeful that their study involving small molecules in saliva will help identify those at risk of developing Alzheimer’s disease – a neurologic condition predicted to reach epidemic proportions worldwide by 2050. Their […]

Alzheimers and Dementia

Mayo Clinic Researchers Uncover New Agents That Eliminate Cells Associated with Age-Related Diseases

Mayo Clinic researchers have uncovered three new agents to add to the emerging repertoire of drugs that aim to delay the onset of aging by targeting senescent cells – cells that contribute to frailty and other age-related conditions. A recent study of human cell cultures shows that the drugs, fisetin and two BCL-XL inhibitors – […]

Alzheimers and Dementia

Researchers Identify How Inflammation Spreads Through the Brain After Injury

Findings Could Transform How Understanding of Brain Injury and Disease Researchers have identified a new mechanism by which inflammation can spread throughout the brain after injury. This mechanism may explain the widespread and long-lasting inflammation that occurs after traumatic brain injury, and may play a role in other neurodegenerative diseases. The findings were published today […]

Alzheimers and Dementia

New Understandings of Cell Death Show Promise for Preventing Alzheimer’s

New research on peptides important to understanding Alzheimer’s disease and their effects on cell toxicity could lead to treatments for preventing or delaying neurodegenerative diseases Alzheimer’s disease is a progressive neurodegenerative disorder that leads to dementia via advanced neuronal dysfunction and death. A person with Alzheimer’s disease suffers loss of control over thought, memory and […]

Alzheimers and Dementia Biotechnology

Georgetown Clinical Trial of Nilotinib in Alzheimer’s Disease Begins

 A clinical trial to examine the effect of nilotinib on clinical outcomes and biomarkers in people with mild to moderate Alzheimer’s disease has opened at Georgetown University Medical Center (GUMC). The clinical trial is a phase II, randomized, double blinded, placebo-controlled study to evaluate the impact of low doses of the cancer drug(Tasigna®). GUMC is […]

Alzheimers and Dementia Biotechnology

Researchers Find a Potential Target for Anti-Alzheimer’s Treatments

Scientists at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg have identified a gene that may provide a new starting point for developing treatments for Alzheimer’s disease (AD). The USP9 gene has an indirect influence on the so-called tau protein, which is believed to play a significant role in the onset […]

Alzheimers and Dementia Biotechnology

Weston Brain Institute Funds Clinical Trials of New Alzheimer’s Treatment

Electrocranial stimulation offers hope for Alzheimer’s patients Funding for clinical trials of a new treatment for Alzheimer’s disease has been announced by the Weston Brain Institute. Dr. Zahra Moussavi, Canada Research Chair in Biomedical Engineering in the Faculty of Engineering, is receiving $1,737,960 for her project on investigating the efficacy of high-frequency rTMS treatment for […]