age-related decline Alzheimers and Dementia

New discoveries predict ability to forecast dementia from single molecule

 Scientists who recently identified the molecular start of Alzheimer’s disease have used that finding to determine that it should be possible to forecast which type of dementia will develop over time – a form of personalized medicine for neurodegenerative diseases. A new study from UT Southwestern shows that single toxic tau proteins that stick together and spread degeneration across the brains of dementia patients have different shapes. The folds of these
age-related decline Alzheimers and Dementia

Scientists Propose a New Lead for Alzheimer’s Research

A University of Adelaide-led team of scientists has suggested a potential link between iron in our cells and the rare gene mutations that cause Alzheimer’s disease, which could provide new avenues for future research. In a paper published in the journal Frontiers in Neuroscience, the team proposes a new theory for how rare gene mutations cause Alzheimer’s disease. A theory that, if proven, could assist in finding a way to prevent the
age-related decline

How summer and diet damage your DNA, and what you can do

  Today, your body will accumulate quadrillions of new injuries in your DNA. The constant onslaught of many forms of damage, some of which permanently mutates your genes, could initiate cancer and prove fatal. Yet all is not doomed: The lives we lead determine how well our cells can handle this daily molecular erosion. Certain cells are particularly at risk. Your skin, for instance, is constantly being bombarded by high-energy
age-related decline

Thyroid Gene Variation May Increase Risk for Alzheimer’s Disease in African Americans

African Americans with a common genetic variation are at increased risk for developing Alzheimer’s disease, while European Americans with the same variation are not, according to a study led by researchers at Rush University Medical Center. They published the study results in the February 22 online issue of the Journal of Clinical Endocrinology and Metabolism. The genetic variation, known as Thr92AlaD2 polymorphism, affects a gene involved in the activation of
age-related decline Alzheimers and Dementia

A New Therapeutic Avenue for Parkinson’s disease

Systemic clearing of senescent astrocytes prevents Parkinson's neuropathology and associated symptoms in a mouse model of sporadic disease, the type implicated in 95% of human cases. Publishing in Cell Reports, researchers in the Andersen lab at the Buck Institute provide a new potential therapeutic avenue for the incurable, progressive neurological disorder that affects up to one million Americans, robbing them of the ability to control movement. Senescent cells, which stop dividing
age-related decline Cell Therapy stem cells

Stem Cells May Be The Key To Staying Strong In Old Age

University of Rochester Medical Center researchers have discovered that loss of muscle stem cells is the main driving force behind muscle decline in old age in mice. Their finding challenges the current prevailing theory that age-related muscle decline is primarily caused by loss of motor neurons. Study authors hope to develop a drug or therapy that can slow muscle stem cell loss and muscle decline in the future. As early