Pharmaceutical Business News

Called Off: Pharmaceutical Giants Pfizer and Allergan to abandon $212 billion merger

US pharmaceutical giant Pfizer has announced it is abandoning plans for a US $160 billion ($212 billion) merger with Botox maker Allergan, citing new US rules cracking down on tie ups aimed at saving on taxes. The deal with the Irish-based firm would have created the world's largest pharmaceutical company. Pfizer said in a statement that the two companies "terminated by mutual agreement" plans to merge. "Pfizer approached this transaction
Biotechnology Cell Therapy

Growing skin in the lab

Using reprogrammed iPS cells, scientists from the RIKEN Center for Developmental Biology (CDB) in Japan have, along with collaborators from Tokyo University of Science and other Japanese institutions, successfully grown complex skin tissue--complete with hair follicles and sebaceous glands--in the laboratory. They were then able to implant these three-dimensional tissues into living mice, and the tissues formed proper connections with other organ systems such as nerves and muscle fibers. This
Cardiology Cell Therapy Clinical Trials

Heart Failure Patients Experience Improved Outcomes Following Novel Stem Cell Treatment

An investigational stem cell therapy derived from patients’ own blood marrow significantly improved outcomes in patients with severe heart failure, according to a study from the Cedars-Sinai Heart Institute. The research was presented as a late-breaking clinical trial at the American College of Cardiology Scientific Sessions in Chicago. “This is an important step forward for heart patients in particular and for stem cell medicine in general,” said Timothy D. Henry,
Biotechnology Diabetes Vaccines

Salmonella-Based Oral Vaccine a Promising Therapy for Preventing Type 1 Diabetes

A combined vaccine therapy including live Salmonella is a safe and effective way to prevent diabetes in mice and may point to future human therapies, a new study finds. The results were unveiled recently at ENDO 2016, the annual meeting of the Endocrine Society, in Boston. The causes of Type 1 diabetes are not fully known. In most cases, the body’s immune system attacks and destroys the part of the
Photo credit: Connie Jiang, MD/PhD student, Perelman, University of Pennsylvania.
Biotechnology Gene Therapy Genomes

Seeing Cell to Cell Differences for First Time Explains Symptoms of Rare Genetic Disorders

Every cell in the body has two genomes, one from the mother and one from the father. Until now, researchers have lacked the tools to examine -- in a single cell --the exact readout from each genome to make RNA. Using a new technology that allows researchers to do just that, an interdisciplinary University of Pennsylvania team examined a rare disease in which these two genomes are expressed differently throughout
Biomarkers cancer Cancer Discovery

New Study Implicates Unusual Class of Circular RNAs in Cancer

Cancer cells are notorious for their genomes gone haywire, often yielding fusion proteins — mash-ups of two disparate genes that, once united, assume new and harmful capabilities. Exactly how such genome scrambling impacts RNA, particularly the vast and mysterious world of non-coding RNA, has been largely unexplored. Now, a team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) offers some early answers by studying an intriguing class of
Cancer Discovery

New Mouse Model for Acute Myeloid Leukemia Opens Door to Research, Possible Treatments

A novel mouse model of a highly lethal form of acute myeloid leukemia (AML) offers a new tool for scientists working to better understand this disease and research new therapeutic targets. Scientists from Cincinnati Children’s Hospital Medical Center developed the model and have already used it to gain important new insights into the genetic mechanisms underlying the disease and to identify promising drug targets. They report their results in the
Biotechnology cancer Clinical Trials Radiopharmaceuticals

FDA Greenlights Orphan Drug Status for Radioimmuneconjugate for Treating Refractory and Relapsed Acute Myeloid Leukemia in Elderly Patients

The U.S. Food and Drug Administration (FDA) has granted orphan drug designation for Iomab-B, a radioimmunotherapeutic that conditions relapsed and refractory Acute Myeloid Leukemia (AML) patients for a Hematopoietic Stem Cell Transplant (HSCT), commonly referred to as a Bone Marrow Transplant (BMT). Iomab-B will soon begin a 150 patient, pivotal Phase 3 multicenter trial in relapsed and refractory AML patients over the age of 55. Iomab-B is a radioimmunoconjugate consisting
Biotechnology Cell Therapy Clinical Trials Diabetes

Sketches Of Progress

By  Richard (Rick) Mills, Editor of Aheadoftheherd.com Disruptive innovations have the potential to truly reshape the world in which we live and work. Regenerative medicine means replacing, engineering or regenerating human cells, tissues or organs with the goal being to re-establish normality for conditions that currently are beyond repair. An example of a highly disruptive technology is regenerative medicine where living therapeutic cells placed within an implanted medical device manufacture
Biomarkers Clinical Trials Diagnostic Testing

New Funding Sought for Development of Diagnostic Test and Therapeutic Drug for Traumatic Brain Injury (TBI)

Medicortex Finland Oy, a start-up biotechnology company focused on the diagnosis and treatment of neurodegenerative conditions has recently launched a funding round and is seeking investors to help fund research and development of a therapeutic drug and companion diagnostic test for Traumatic Brain Injury (TBI). The company aims to identify a TBI biomarker and, on this basis, develop a diagnostic test for the evaluation of TBI presence and severity. The
Biotechnology

Looking at the Bacteria Inside: A New Method of Viewing TB Bacteria

Although tuberculosis (TB) is commonly thought of as being a disease that mainly affects nineteenth century poets and Victor Hugo characters, it is still the second-most common cause of mortality from an infectious disease in the world, killing nearly three people every minute. Every March 24, on World TB Day, the global health community recognizes the work of Robert Koch, who announced on that date in 1882 his discovery of
Radiopharmaceuticals rare diseases

Pharma Company Funds Saint Louis University Researcher’s Quest to Treat His Daughter’s Disease

A team of Saint Louis University scientists led by Fran Sverdrup, Ph.D., developing a treatment for his daughter’s muscular dystrophy, has new funding for their research, thanks in part to a California-based biopharmaceutical company named Ultragenyx, which is focused on the development of novel products for rare and ultra-rare diseases. SLU’s Center for World Health and Medicine, has entered into a three-year collaboration to advance a potential treatment identified by
Biotechnology cancer Clinical Trials

Cancer Immunotherapies take Center Stage

[embed]https://vimeo.com/151833021[/embed] The newly created task force on cancer, in what Vice President Joe Biden has called a “moon shot” to cure the disease, is to put the US on a path to achieve in just five years research and treatment that otherwise might take a decades or more.  Although the memorandum does not commit the government to major new spending, the task force's role will be to focus on making
Biotechnology cancer Clinical Trials

Many Targeted Cancer Therapies Suppress T Cell Immune Responses

In many cases, targeted therapies for cancer are preferred as treatments over chemotherapy and surgery because they attack and kill cancer cells with specific tumor-promoting mutations while sparing healthy, normal cells that do not express these mutations. In clinical trials, a heavy emphasis on the effects of targeted therapies on tumor cells has been explored, but the effects they have on the immune system have not been thoroughly investigated. However,
cancer Clinical Trials

UGA Researchers Find Potential Treatment for Prostate Cancer

Researchers at the University of Georgia have created a new therapeutic for prostate cancer that has shown great efficacy in mouse models of the disease. They published their findings recently in the journal Nanomedicine: Nanotechnology, Biology and Medicine. The treatment is designed to inhibit the activity of a protein called PAK-1, which contributes to the development of highly invasive prostate cancer cells. Aside from non-melanoma skin cancer, prostate cancer is
Arthritis Biotechnology Clinical Trials Pharmaceuticals Prescriptions

New Study Shows Common NSAIDs can cause more Harm than Good

Many patients around the world, are prescribed non-steroidal anti-inflammatory drugs (called NSAIDs) for the treatment of painful conditions, fever and inflammation. But the treatment also comes with side effects, including the risk of ulcers and increased blood pressure. A major new study from Denmark complied new research that demonstrated that a common arthritis medicine is particularly dangerous for heart patients. The study also uncovered that older types of arthritis medicine,
Laboratory Technology Medical Devices

New Technology Aims to turn Complicated Lab Tests into Point-of-Care Tests for First Responders

Carbon monoxide (CO) poisoning can have tragic consequences if victims are not rescued or treated. First responders at the scene may not know immediately if a conscious patient is a victim of CO poisoning. Normally, these type of tests are taken with an arterial blood sample (typically an artery in the arm), and are then sent off to a central lab, where a bench top unit uses spectroscopy and electrochemical
Diabetes Medical Devices

Introducing the Dario: The world’s largest glucose monitoring market, gets user-centric mHealth product that brings diabetes management into the digital age

Americans living with diabetes are now able to incorporate their phones as a tool for managing their blood glucose measurements. Labstyle Innovation’s user-centric mHealth product, the Dario Blood Glucose Monitoring System, neatly brings diabetes management into the digital age. The Dario Blood Glucose Monitoring System consists of an all-in-one Smart Meter that plugs directly into smartphones coupled with a robust, real-time mobile app, that allows users to track and monitor