Biotechnology Diabetes

Solving a Genetic Mystery in Type 1 Diabetes

In type 1 diabetes, the immune system attacks the body’s own insulin-producing cells. Scientists understand reasonably well how this autoimmune attack progresses, but they don’t understand what triggers the attack or how to stop it, says Stephan Kissler, Ph.D., Investigator in the Section on Immunobiology at Joslin Diabetes Center and Assistant Professor of Medicine at […]

Antibiotics

New Potent Nanodrug to Combat Antibiotic-Resistant Infections

A research team led by University of Arkansas chemist Jingyi Chen and University of Arkansas for Medical Sciences microbiologist Mark Smeltzer has developed an alternative therapeutic approach to fighting antibiotic-resistant infections. The novel method uses a targeted, light-activated nanodrug consisting of antibiotic-loaded nanoconstructs, which are nanoscale cages made of gold and coated with polydopamine. The […]

Biotechnology Pharmaceutical Business News Pharmaceuticals

Q&A with Denis Corin, Q Bio Med Inc – Getting Past the “Pharma Bro” – Smaller Biotech Continue to Strive for Well-Being of Patients

There has been a vast amount of mixed feelings surrounding the biotech/drug company development of drugs and the final price consumers/patients are paying. Especially when one biotech CEO, Martin Shkreli (aka ‘Pharma Bro”) decided to massively increase of a very cheap drug vital to patients with HIV from $13.50 to $750. The actions of one CEO […]

Pharmaceutical Business News

Called Off: Pharmaceutical Giants Pfizer and Allergan to abandon $212 billion merger

US pharmaceutical giant Pfizer has announced it is abandoning plans for a US $160 billion ($212 billion) merger with Botox maker Allergan, citing new US rules cracking down on tie ups aimed at saving on taxes. The deal with the Irish-based firm would have created the world’s largest pharmaceutical company. Pfizer said in a statement […]

Biotechnology Cell Therapy

Growing skin in the lab

Using reprogrammed iPS cells, scientists from the RIKEN Center for Developmental Biology (CDB) in Japan have, along with collaborators from Tokyo University of Science and other Japanese institutions, successfully grown complex skin tissue–complete with hair follicles and sebaceous glands–in the laboratory. They were then able to implant these three-dimensional tissues into living mice, and the […]

Cardiology Cell Therapy Clinical Trials

Heart Failure Patients Experience Improved Outcomes Following Novel Stem Cell Treatment

An investigational stem cell therapy derived from patients’ own blood marrow significantly improved outcomes in patients with severe heart failure, according to a study from the Cedars-Sinai Heart Institute. The research was presented as a late-breaking clinical trial at the American College of Cardiology Scientific Sessions in Chicago. “This is an important step forward for […]

Biomarkers cancer Cancer Discovery

New Study Implicates Unusual Class of Circular RNAs in Cancer

Cancer cells are notorious for their genomes gone haywire, often yielding fusion proteins — mash-ups of two disparate genes that, once united, assume new and harmful capabilities. Exactly how such genome scrambling impacts RNA, particularly the vast and mysterious world of non-coding RNA, has been largely unexplored. Now, a team led by investigators at Beth […]

Cancer Discovery

New Mouse Model for Acute Myeloid Leukemia Opens Door to Research, Possible Treatments

A novel mouse model of a highly lethal form of acute myeloid leukemia (AML) offers a new tool for scientists working to better understand this disease and research new therapeutic targets. Scientists from Cincinnati Children’s Hospital Medical Center developed the model and have already used it to gain important new insights into the genetic mechanisms […]

Biotechnology cancer Clinical Trials Radiopharmaceuticals

FDA Greenlights Orphan Drug Status for Radioimmuneconjugate for Treating Refractory and Relapsed Acute Myeloid Leukemia in Elderly Patients

The U.S. Food and Drug Administration (FDA) has granted orphan drug designation for Iomab-B, a radioimmunotherapeutic that conditions relapsed and refractory Acute Myeloid Leukemia (AML) patients for a Hematopoietic Stem Cell Transplant (HSCT), commonly referred to as a Bone Marrow Transplant (BMT). Iomab-B will soon begin a 150 patient, pivotal Phase 3 multicenter trial in […]

Biotechnology Cell Therapy Clinical Trials Diabetes

Sketches Of Progress

By  Richard (Rick) Mills, Editor of Aheadoftheherd.com Disruptive innovations have the potential to truly reshape the world in which we live and work. Regenerative medicine means replacing, engineering or regenerating human cells, tissues or organs with the goal being to re-establish normality for conditions that currently are beyond repair. An example of a highly disruptive […]

Biomarkers Clinical Trials Diagnostic Testing

New Funding Sought for Development of Diagnostic Test and Therapeutic Drug for Traumatic Brain Injury (TBI)

Medicortex Finland Oy, a start-up biotechnology company focused on the diagnosis and treatment of neurodegenerative conditions has recently launched a funding round and is seeking investors to help fund research and development of a therapeutic drug and companion diagnostic test for Traumatic Brain Injury (TBI). The company aims to identify a TBI biomarker and, on […]

Radiopharmaceuticals rare diseases

Pharma Company Funds Saint Louis University Researcher’s Quest to Treat His Daughter’s Disease

A team of Saint Louis University scientists led by Fran Sverdrup, Ph.D., developing a treatment for his daughter’s muscular dystrophy, has new funding for their research, thanks in part to a California-based biopharmaceutical company named Ultragenyx, which is focused on the development of novel products for rare and ultra-rare diseases. SLU’s Center for World Health […]

Biotechnology cancer Clinical Trials

Many Targeted Cancer Therapies Suppress T Cell Immune Responses

In many cases, targeted therapies for cancer are preferred as treatments over chemotherapy and surgery because they attack and kill cancer cells with specific tumor-promoting mutations while sparing healthy, normal cells that do not express these mutations. In clinical trials, a heavy emphasis on the effects of targeted therapies on tumor cells has been explored, […]

cancer Clinical Trials

UGA Researchers Find Potential Treatment for Prostate Cancer

Researchers at the University of Georgia have created a new therapeutic for prostate cancer that has shown great efficacy in mouse models of the disease. They published their findings recently in the journal Nanomedicine: Nanotechnology, Biology and Medicine. The treatment is designed to inhibit the activity of a protein called PAK-1, which contributes to the […]

Arthritis Biotechnology Clinical Trials Pharmaceuticals Prescriptions

New Study Shows Common NSAIDs can cause more Harm than Good

Many patients around the world, are prescribed non-steroidal anti-inflammatory drugs (called NSAIDs) for the treatment of painful conditions, fever and inflammation. But the treatment also comes with side effects, including the risk of ulcers and increased blood pressure. A major new study from Denmark complied new research that demonstrated that a common arthritis medicine is […]

Laboratory Technology Medical Devices

New Technology Aims to turn Complicated Lab Tests into Point-of-Care Tests for First Responders

Carbon monoxide (CO) poisoning can have tragic consequences if victims are not rescued or treated. First responders at the scene may not know immediately if a conscious patient is a victim of CO poisoning. Normally, these type of tests are taken with an arterial blood sample (typically an artery in the arm), and are then […]