cancer Cancer Discovery

New Metric Defines Areas of Highest Prostate Cancer Burden

To catch prostate cancer at earlier stages, when it’s more easily treated, many institutions do community outreach and education sessions to explain why cancer screenings can be life-saving. In order to have the highest impact, however, institutions must select where to focus their efforts. Prostate cancer is most common among African American men and can […]

Infectious Diseases

New Lyme Disease Tests Could Offer Quicker, More Accurate Detection

New tests to detect early Lyme disease – which is increasing beyond the summer months – could replace existing tests that often do not clearly identify the infection before health problems occur. In an analysis published on December 7 in Clinical Infectious Diseases, scientists from Rutgers University, Harvard University, Yale University, the National Institute of Allergy […]

Pharmaceutical Business News

Shire bid marks Takeda’s latest – and biggest – push for global status

(Reuters) Takeda Pharmaceutical Co Ltd’s $64 billion bid for London-listed rare disease specialist Shire Plc bolsters its credentials as Japan’s most outward facing drugs firm, a mold-breaking image that has been more than a decade in the making. Under chief executive Christophe Weber and his predecessor, Yasuchika Hasegawa, Takeda has cut its exposure to Japan, […]

Biotechnology Cell Therapy

New Cell Therapy Aids Heart Recovery—Without Implanting Cells

Columbia biomedical engineers invent innovative technique to help injured hearts regenerate, through therapeutic application of extracellular vesicles secreted by cardiomyocytes derived from human pluripotent stem cells Heart disease is a major global health problem–myocardial infarction annually affects more than one million people in the U.S. alone, and there is still no effective treatment. The adult […]

Biotechnology Uncategorized

Doctors Prescribe Opioids at High Rates to Those at Increased Overdose Risk, but Trends Improving, Study Finds

Use with anti-anxiety drug benzodiazepine may be linked to rise in opioid-related deaths The number of first-time prescriptions for opioid drugs has not risen since about 2010, according to UCLA researchers. However, patients taking a class of drug known to increase the risk for overdoses were likelier to receive a first-time opioid prescription — a […]

Alzheimers and Dementia

A Common Anti-Inflammatory Therapy May Help Reduce the Risk of Developing Parkinson’s Disease

A recent study from researchers at the Icahn School of Medicine at Mount Sinai provides new insights into a link between inflammatory bowel disease (IBD) and Parkinson’s disease, and may have significant implications for the treatment and prevention of Parkinson’s disease. The recent study, published in JAMA Neurology, shows that individuals with IBD are at […]

Neurology

Defect in Debilitating Neurodegenerative Disease Reversed in Mouse Nerves

Scientists have developed a new drug compound that shows promise as a future treatment for Charcot-Marie-Tooth disease, an inherited, often painful neurodegenerative condition that affects nerves in the hands, arms, feet and legs. The researchers used the compound to treat the nerves of mice harboring the genetic defects that cause the disease. The new study, […]

Neurodegenerative diseases Neurology

Preliminary Study Suggests Drug May Help Babies with Spinal Muscular Atrophy

A preliminary study suggests that an investigational drug may help increase protein levels in babies with spinal muscular atrophy. The open-label study is released today and will be presented at the American Academy of Neurology’s 70th Annual Meeting in Los Angeles, April 21 to 27, 2018. Spinal muscular atrophy (SMA) is an inherited disease that […]

Neurodegenerative diseases Neurology Parkinson's

A Single Concussion May Increase Risk of Parkinson’s Disease

People who have been diagnosed with a mild concussion, or mild traumatic brain injury, may have a 56 percent increased risk of developing Parkinson’s disease, according to a study published in the April 18, 2018, online issue of Neurology®, the medical journal of the American Academy of Neurology. “Previous research has shown a strong link […]

cancer Cancer Discovery

Early Skin Cancer More Accurately Diagnosed by Dermatologist Than Other Providers

Physician assistants (PAs) are increasingly used in dermatology practices to cut costs and improve access to care, but are more likely than dermatologists to perform unnecessary skin biopsies to check for cancer, while being less likely to accurately diagnose early stage skin cancers, according to new research conducted by the University of Pittsburgh School of Medicine. […]

Biotechnology cancer rare diseases

Study Reports Possible Novel Method for Stopping Untreatable Pediatric Brain Cancer

Researchers used an experimental molecular therapy in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer and now propose advancing the treatment to clinical testing in children. Scientists at the Cincinnati Children’s Cancer and Blood Diseases Institute report in the journal Molecular Cancer Therapeutics testing the small molecule 6-thio-2’deoxyguanosine (6-thio-dG) in […]

Biotechnology cancer Uncategorized

When Prostate Cancer Reaches Bone, Bone Cells May Drive Overall Growth of the Disease

When prostate cancer metastasizes to bone, it can become especially dangerous – not only with its action in the bone but, interestingly, with increased aggressiveness of the overall cancer itself. Now, research presented at the American Association for Cancer Research (AACR) Annual Meeting 2018 hints at why: Cells involved in these bone metastases may release […]

Biotechnology cancer Cell Therapy

Drug Reduces Size of Some Lung Cancer Tumors, Relapse Rate After Surgery

A drug given to early stage lung cancer patients before they undergo surgery showed major tumor responses in the removed tumor and an increase in anti-tumor T-cells that remained after the tumor was removed, which resulted in fewer relapse cases in the patients. The research teams at the Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy, […]

cancer Cancer Discovery

Novel Clinical Tool to Predict Patient Survival Rate and Treatment Outcomes for Early-Stage Lung Cancer

A team of researchers, led by Professor Lim Chwee Teck from the Department of Biomedical Engineering at the National University of Singapore (NUS) and NUS PhD candidate Ms Lim Su Bin, has leveraged open source data to develop a personalised risk assessment tool that can potentially predict patient survival rate and treatment outcomes of early-stage […]

cancer Cancer Discovery

Simultaneous Chemotherapy and Immunotherapy May Be Better for Some Metastatic Bladder Cancer Patients

Researchers from Mount Sinai and Sema4, a health information company and Mount Sinai venture, have discovered that giving metastatic bladder cancer patients simultaneous chemotherapy and immunotherapy is safe and that patients whose tumors have certain genetic mutations may respond particularly well to this combination approach, according to the results of a clinical trial published in European […]

Biotechnology cancer Cancer Discovery Uncategorized

Identifying a New Therapeutic Target for the Most Common Type of Lung Cancer

Research by Rutgers Cancer Institute of New Jersey investigators has identified novel functions of the superoxide dismutase 1 (SOD1) enzyme providing support that it could serve as a therapeutic target in the most common type of lung cancer. Results of the work are being presented as part of a poster session at the American Association […]

Biotechnology cancer Pharmaceuticals Prodrug

New Drug Combo Improves Survival of Women with Rare Uterine Cancer

Adding the monoclonal antibody drug trastuzumab—already used to treat certain breast cancers—to the chemotherapy regimen of women with a rare form of uterine cancer lengthens the amount of time their tumors are kept from growing, according to Johns Hopkins Medicine researchers conducting a small phase II trial of the regimen, testing its safety and value. […]