Clinical Trials

A hangover pill? Tests on drunk mice show promise

By bogdanhoda/Shutterstock.com Yunfeng Lu, University of California, Los Angeles “Civilization begins with distillation,” said William Faulkner, a writer and drinker. Although our thirst for alcohol dates back to the Stone Age, nobody has figured out a good way to deal with the ensuing hangover after getting drunk. As a chemical engineering professor and wine enthusiast, […]

cancer Cancer Discovery

Analysis of Prostate Tumors Reveals Clues to Cancer’s Aggressiveness

Sequencing reveals genetic errors common in metastatic tumors Using genetic sequencing, scientists have revealed the complete DNA makeup of more than 100 aggressive prostate tumors, pinpointing important genetic errors these deadly tumors have in common. The study lays the foundation for finding new ways to treat prostate cancer, particularly for the most aggressive forms of […]

Biotechnology

CRISPR/Cas9 gene editing scissors are less accurate than we thought, but there are fixes

by Gaetan Burgio CRISPR gene editing technology is revolutionizing medicine and biology. This technique allows scientists to edit DNA with more precision and greater ease than previous gene editing technology. But a new study has called into question the precision of the technique. The hope for gene editing is that it will be able to […]

Healthcare IT News

H1 Announces Expansion of Healthcare Machine Learning Analytics Platforms

H1, a New York-based healthcare data-driven solutions provider, today announced continued growth and expansion of its global healthcare analytics platforms marked by strong top-line revenue growth. In the past year, H1 has grown from an initial team of five employees to over 150 employees globally, with international offices in New York, London, Seattle, and Hyderabad, India. With a team of over […]

Neurodegenerative diseases

Novel therapy delays muscle atrophy in Lou Gehrig’s disease model

Supplementing a single protein found in the spinal cord could help prevent symptoms of Lou Gehrig’s disease, according to a new study out of Case Western Reserve University School of Medicine. Researchers found high levels of the protein–called mitofusion 2 or Mfn2–prevented nerve degeneration, muscle atrophy, and paralysis in a mouse model of the disease. […]

Breast Cancer

Potential new surgical options for women with multiple ipsilateral breast cancer

A new multi-institutional clinical trial compared outcomes of women with multiple ipsilateral breast cancer, or more than one site of disease in the same breast, who underwent breast-conserving surgery, with outcomes of those who converted to mastectomy. Out of 198 eligible women in the trial, 184 (92.9%) successfully completed breast-conserving surgery, 134 of those with […]

Surgery

Robotic Surgery as Effective as Open Surgery for Bladder Cancer

Robotic surgery is as effective as traditional open surgery in treating bladder cancer, according to a landmark study published in the journal Lancet. Three Loyola Medicine urologists, Marcus Quek, MD, Gopal Gupta, MD, and Alex Gorbonos, MD, are co-authors of the study. First author is Dipen Parekh, MD, of the University of Miami. Loyola is among 15 centers that […]

Biotechnology Pharmaceuticals rare diseases

Researchers Discover Llama-Derived Nanobody Can Be Used as Potential Therapy for Hard-to-Treat Diseases

Researchers from Case Western Reserve University School of Medicine have found a nanobody that holds promise to advance targeted therapies for a number of neurological diseases and cancer. In a recent study published in Nature Communications, Sahil Gulati, of the Department of Pharmacology at Case Western Reserve School of Medicine, and colleagues identified a nanobody derived […]

Biotechnology Clinical Trials Pharmaceuticals rare diseases

New Insight Into Huntington’s Disease May Open Door to Drug Development

McMaster University researchers have developed a new theory on Huntington’s disease which is being welcomed for showing promise to open new avenues of drug development for the condition. Huntington’s disease is caused by a mutation in the gene that makes the protein called huntingtin. A team of researchers led by McMaster has found there is […]

Biotechnology cancer Clinical Trials Uncategorized

Brain metastases common and difficult to treat in ROS1 lung cancer

Increasingly, doctors are treating lung cancer based on the genetic rearrangements driving the disease. For example, cancers that are driven by changes in the genes ALK, EGFR, and ROS1 can now all be paired with drugs that target these specific changes. However, these cancers are not only dangerous in the lung where they appear, but […]

Immunotherapies

Scientists Identify a Protein Complex That Shapes the Destiny of T Cells

Like a mentor helping medical students choose between specialties, a protein complex helps shape the destiny of developing T cells, St. Jude Children’s Research Hospital scientists have reported. The research appears today in the journal Science Immunology and adds to growing evidence of the critical role cell metabolism plays in the immune system. The protein […]

Infectious Diseases

Higher Doses of Rifampin Appear More Effective in Fighting TB Without Increasing Risk of Adverse Events

Higher daily doses of rifampin, a cornerstone of tuberculosis treatment, killed more TB bacteria in sputum cultures, and the higher doses did so without increasing the adverse effects of treatment, according to a randomized controlled trial published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine. In “Efficacy and Safety of High-Dose Rifampin […]

Biotechnology Clinical Trials Diabetes

Experimental Drug Stops Parkinson’s Disease Progression in Mice

Johns Hopkins researchers say they have developed an experimental drug, similar to compounds used to treat diabetes, that slows the progression of Parkinson’s disease itself — as well as its symptoms — in mice. In experiments performed with cultures of human brain cells and live mouse models, they report the drug blocked the degradation of […]