cancer Clinical Trials

Phase I Clinical Trial Shows Some Promise for Investigational Drug for Melanoma

An investigational compound designed to block a hyperactive cell growth signal in advanced melanoma and other cancers has shown some promise in an early-stage clinical trial, researchers at the University of North Carolina Lineberger Comprehensive Cancer Center and other institutions have reported. In JCI Insight, UNC Lineberger’s Stergios Moschos, MD, and colleagues published the results […]

Biotechnology

Cell Pouch Regenerative Medicine Clinical Trial for Patients with Type 1 Diabetes Supported with Continuous Glucose Monitoring Systems

Patients undergoing an upcoming Phase I/II single site, single arm clinical trial using Sernova’s signature cell pouch technology, will be provided with a glucose monitoring system from Medtronic Minimed, Northridge, CA. Sernova, a clinical stage company developing regenerative medicine technologies for the treatment of chronic diseases including diabetes and hemophilia, announced continuous glucose monitoring systems […]

Biotechnology Heart Health Regenerative Medicine

Resolvin D-1 Limits Kidney Damage After Heart Attacks

A heart attack triggers an acute inflammatory response at the damaged portion of the heart’s left ventricle. If this acute inflammation lingers, it can lead to stretching of the ventricle and heart failure. The inflammation can claim another victim — the kidneys. New research shows that a bioactive compound called resolvin D-1, injected as a […]

Biotechnology Cell Therapy Clinical Trials Infectious Diseases

Research with Zebrafish May Lead to Treatment for Blinding Disorders, Including Glaucoma

Jakub Famulski, an assistant professor of biology in the University of Kentucky College of Arts and Sciences, has received a grant for over $1.8 million from the National Institutes of Health to study the early formation of the anterior segment of the eye. The research has the potential to lead to more treatment options for patients with blinding disorders. […]

Pharmaceutical Business News

FDA expands approval of Imfinzi to reduce the risk of non-small cell lung cancer progressing

The U.S. Food and Drug Administration today approved Imfinzi (durvalumab) for the treatment of patients with stage III non-small cell lung cancer (NSCLC) whose tumors are not able to be surgically removed (unresectable) and whose cancer has not progressed after treatment with chemotherapy and radiation (chemoradiation). “This is the first treatment approved for stage III […]

Cancer Discovery

Is anti-angiogenic therapy to treat glioblastomas a viable option?

Results of two phase 2 clinical trials testing cabozantinib suggest that anti-angiogenic therapy could be used to treat glioblastomas Glioblastoma is an aggressive type of brain tumor that affects approximately 74,000 individuals across the world, annually. The current standard of treatment for this tumour type consists of surgical removal of the tumor, accompanied with radiation […]

Neurology

FDA authorizes marketing of first blood test to aid in the evaluation of concussion in adults

The U.S. Food and Drug Administration today permitted marketing of the first blood test to evaluate mild traumatic brain injury (mTBI), commonly referred to as concussion, in adults. The FDA reviewed and authorized for marketing the Banyan Brain Trauma Indicator in fewer than 6 months as part of its Breakthrough Devices Program. Most patients with […]

Biotechnology Cell Therapy Regenerative Medice stem cells

New Stem-Cell Based Stroke Treatment Repairs Damaged Brain Tissue

A team of researchers at the University of Georgia’s Regenerative Bioscience Center and ArunA Biomedical, a UGA startup company, have developed a new treatment for stroke that reduces brain damage and accelerates the brain’s natural healing tendencies in animal models. They published their findings in the journal Translational Stroke Research. The research team led by […]

Alzheimers and Dementia

Researchers Successfully Reverse Alzheimer’s Disease in Mouse Model

A team of researchers from the Cleveland Clinic Lerner Research Institute have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer’s disease, thereby improving the animals’ cognitive function. The study, which will be published February 14 in the Journal of Experimental Medicine, raises […]

Biotechnology Cell Therapy Clinical Trials

A Protein Could Make Stem Cell Therapy for Heart Attack Damage More Effective

Researchers may have found a way to reduce ongoing heart damage that occurs long after a severe heart attack by improving the longevity of stem cells injected into the heart. The new study shows that a protein infused into the bloodstream, can improve the healing properties of stem cell therapy in animal models of the […]

Biotechnology cancer Immunotherapies rare diseases

Smart Bomb Virus Shows Promise as Brain Tumor Immunotherapy

A common cold virus engineered to attack the most common and deadly of brain tumors allowed 20 percent of patients with recurrent glioblastoma to live for three years or longer, researchers from The University of Texas MD Anderson Cancer Center report on a phase I clinical trial in the Journal of Clinical Oncology. The altered […]