cancer Cancer Discovery

Loss of Tight Junction Protein Promotes Development of Precancerous Cells

Tight junctions are multi-protein complexes that serve as barriers in epithelial tissues such as the skin or lining of the gut. Loss of a specific tight junction barrier protein, claudin 18, occurs in the majority of gastric cancer patients and is correlated with poor prognosis in patients with advanced gastric cancer. Understanding how claudin 18 […]

Biotechnology Pharmaceutical Business News

Q BioMed Announces Strategic Partnership and Preclinical Development of Treatment for Pediatric Nonverbal Disorder in Autistic Children

Collaboration with SRI Provides QBioMed Expertise in Formulation Development and Preclinical Work in Autism, as well as CMC and Manufacturing capability Q BioMed Inc., a biotechnology accelerationcompany, announced a collaborative agreement with SRIInternational to provide formulation development, preclinical development, andearly clinical manufacturing of QBM-001, in support of Q BioMed’s AutisticSpectrum Disorder (ASD) drug development program […]

age-related decline Alzheimers and Dementia

New discoveries predict ability to forecast dementia from single molecule

 Scientists who recently identified the molecular start of Alzheimer’s disease have used that finding to determine that it should be possible to forecast which type of dementia will develop over time – a form of personalized medicine for neurodegenerative diseases. A new study from UT Southwestern shows that single toxic tau proteins that stick together and […]

Alzheimers and Dementia

New Generation of Therapeutics Based on Understanding of Aging Biology Show Promise for Alzheimer’s Disease

 A scientific strategy that explores therapeutic targets based on the biology of aging is gaining ground as an effective approach to prevent and treat Alzheimer’s disease, accordingdd to research published in the December 7, 2018 online issue of Neurology®. A comprehensive review of the clinical trial landscape, including current agents being studied for the prevention and […]

Alzheimers and Dementia

Johns Hopkins Team Identifies Promising Diagnostic Tool For Alzheimer’s Disease

 Researchers at Johns Hopkins Medicine have identified in live human brains new radioactive “tracer” molecules that bind to and “light up” tau tangles, a protein associated with a number of neurodegenerative diseases including Alzheimer’s disease and other related dementias. Two studies will be published back-to-back in the December issue of Journal of Nuclear Medicine—one as featured […]

cancer Cancer Discovery Cancer screening Clinical Trials

Early Clinical Trial Data Show Gene Therapy Reversing Sickle Cell Anemia

After over a decade of preclinical research and development, a new gene therapy treatment for Sickle Cell Anemia (SCA) is reversing disease symptoms in two adults and showing early potential for transportability to resource-challenged parts of the world where SCA is most common.  Preliminary data from a pilot Phase 1-2 clinical trial testing the gene-addition therapy […]

Biotechnology Cell Therapy Clinical Trials Immunotherapies stem cells

Dana-Farber researchers report clinical trial results in treatment of leukemia and lymphoma

New results from clinical trials of immunotherapy and experimental targeted agents for patients with leukemia and lymphoma are being presented by Dana-Farber Cancer Institute researchers at the American Society of Hematology (ASH) Annual Meeting Dec. 1-4.  Here are summaries of three presentations, including one that compared outcomes of CAR T-cell therapy in patients in clinical […]

Infectious Diseases

HIV in Liver Cells Found to Be Inactive, Narrowing Potential Treatment Targets

 In a proof-of-principle study, researchers at Johns Hopkins revealed that certain immune system cells found in the human liver, called liver macrophages, contain only inert HIV and aren’t likely to reproduce infection on their own in HIV-infected people on long-term antiretroviral therapy (ART). ART is a regimen containing combinations of HIV-targeting drugs that prevents the […]

stem cells

Platelets grown from stem cells may be alternative to donated platelets

Researchers have developed a way to grow human platelets in the laboratory from stem cells derived from fat tissue. The achievement, reported today in the journal Blood, suggests manufactured platelets could eventually reduce the reliance on donated platelets to help patients with cancer and other disorders. Platelets are a component of blood that helps with clotting. Platelet […]

Alzheimers and Dementia

Potential Breakthrough for Lewy Body Dementia

IntraBio Inc., a late-stage biopharmaceutical company developing novel therapies for common and rare (“orphan”) neurodegenerative diseases, announced results for its lead compound series (IB1000s) for the treatment of dementia, including positive clinical results from compassionate-use studies in patients with Lewy Body Dementia and Fronto-Temporal Dementia, and from pre-clinical studies in Alzheimer’s Disease. Recent compassionate-use studies with […]

Infectious Diseases

Patients with Rare Natural Ability to Suppress HIV Shed Light on Potential Functional Cure

Researchers at Johns Hopkins have identified two patients with HIV whose immune cells behave differently than others with the virus and actually appear to help control viral load even years after infection. Moreover, both patients carry large amounts of virus in infected cells, but show no viral load in blood tests. While based on small […]

cancer Cancer Discovery Cancer screening

Johns Hopkins Researchers Advance Role of Circulating Tumor DNA to Detect Early Melanoma Growth, Uncover Treatment Options

Researchers at the Johns Hopkins Kimmel Cancer Center say they have added to evidence that measuring and monitoring tumor DNA that naturally circulates in the blood of melanoma patients can not only reliably help reveal the early stages of cancer growth and spread but also uncover new treatment options that tumor genetic analysis alone may not. “For […]

rare diseases

FDA approves first treatment specifically for patients with rare and life-threatening type of immune disease

The U.S. Food and Drug Administration today approved Gamifant (emapalumab-lzsg) for the treatment of pediatric (newborn and above) and adult patients with primary hemophagocytic lymphohistiocytosis (HLH) who have refractory, recurrent or progressive disease or intolerance with conventional HLH therapy. This FDA approval is the first for a drug specifically for HLH. “Primary HLH is a […]

cancer Cancer Discovery Cancer screening

Enzyme Discovery Points Researchers Toward Starving Lung Cancer as a Potential Treatment

 UT Southwestern researchers have found that an enzyme on the surface of some lung cancer cells helps feed the cancer, making it a tempting treatment target. The enzyme, transmembrane serine protease 11B (TMPRSS11B) is described in a report published today in the journal Cell Reports. In addition to being found in squamous cell lung cancer and prostate […]

cancer Cancer Discovery Cancer screening

A study suggests that epigenetic treatments could trigger the development of aggressive tumours

Cancer develops as a result of the accumulation of mutations in our cells. These mutations are not distributed evenly in our chromosomes, so some regions hold more than others. A study headed by the Institute for Research in Biomedicine (IRB Barcelona) and published in the journal Nature Cell Biologyexamined whether the opening of chromatin (a complex […]

cancer Cancer Discovery Cancer screening

Researchers stop ‘sneaky’ cancer cells in their tracks

A new study by University of Minnesota biomedical engineers shows how they stopped cancer cells from moving and spreading, even when the cells changed their movements. The discovery could have a major impact on millions of people undergoing therapies to prevent the spread of cancer within the body. The research is published today in Nature Communications, a […]

Alzheimers and Dementia

DNA Vaccine Reduces Both Toxic Proteins Linked to Alzheimer’s

A DNA vaccine tested in mice reduces accumulation of both types of toxic proteins associated with Alzheimer’s disease, according to research that scientists say may pave the way to a clinical trial. A new study by UT Southwestern’s Peter O’Donnell Jr. Brain Institute shows that a vaccine delivered to the skin prompts an immune response that reduces […]

Biotechnology Clinical Trials Research & Discovery

WVU first site to launch clinical trial utilizing non-opioid micropellet implant for chronic pain

As part of an ongoing commitment to battle opioid addiction, the Rockefeller Neuroscience Institute at West Virginia University today marked a major milestone, enrolling the first patient in a randomized clinical trial that will test the effectiveness of an injectable non-opioid, non-steroid micropellet to treat sciatica. The phase III clinical trial utilizes a clonidine micropellet, […]

Biotechnology cancer Cancer Discovery Cell Therapy drug development

Anti-Malaria Drugs Have Shown Promise in Treating Cancer, and Now Researchers Know Why

Anti-malaria drugs known as chloroquines have been repurposed to treat cancer for decades, but until now no one knew exactly what the chloroquines were targeting when they attack a tumor. Now, researchers from the Abramson Cancer Center of the University of Pennsylvania say they have identified that target – an enzyme called PPT1 – opening […]